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Consistently, the decline of SYP, PSD95, and BDNF protein occurred earlier and with greater severity in APP/PS1 mice compared to WT mice, indicating that ethanol exposure may cause more neuroinflammatory damage in APP/PS1 mice at molecular level

PloS one 2012;7, e45069, doi:10.1371/journal.pone.0045069

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The article describes these as objective evidence of cardiometabolic dysfunction, which helps a provider frame the request as treatment of metabolic disease rather than a cosmetic concern

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