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10.1016/j.vph.2018.02.010 147 VukojevicJ.VrdoljakB.MalekinusicD.SiroglavicM.MilavicM.KolencD.et al (2020)

Vitamin B12, or cobalamin, has a cobalt ion at its center

10.1038/sj.jid.5700701 42 EmmersonS.MukherjeeS.Melendez-MunozJ.CousinsF.EdwardsS

DSIP was originally discovered in rabbit brain tissue, where it was first isolated as a sleep promoting factor

However, persistent stimulation of Nrf2 response can promote cell survival and create an optimal environment for cell proliferation and consequent tumour transformation