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Beyond a year, the rate might slow

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An orally available tyrosine kinase inhibitor that works by blocking the BCR-ABL1 fusion protein, Scemblix received accelerated approval in November 2021 for patients with Philadelphia chromosome-positive, chronic phase CML and full approval for patients in this population whose cancer carries the T315I mutation

3.11 Enzymatic activity of MDH The enzymatic activity of the proposed MDH was initially demonstrated in pathway reconstitution experiments

At baseline, 20.7% of the patients had an eGFR of 3059 ml/min/1.73 m 2 and 2.4% had an eGFR of 30 mg/g) (Mann et al., 2018)