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The effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity

The mechanism of action involves increased glucose-dependent insulin secretion, potentiation by glucagon-like-peptide-1 and forskolin, protection against apoptosis in diabetic cell lines, and reduction of apoptosis induced by inflammatory factors

And a study of 14,053 Weight Watchers members found that nearly half of people who drink had reduced their alcohol use after starting a GLP-1

FEBS Lett 596:13561364 Wu H, Liu W, Xie X, Jiang S, Ma Q, Shuai Z (2022) Genetically engineered bacterium for producing ergothioneine, and construction method and application thereof

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Cells were lysed by ultrasonication (Sonic Dismembrator Model 500, Fisher Scientific), and the lysate was clarified by centrifugation (35,000 g, 30 min)