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Gastrointestinal Tolerability of Once-Weekly Semaglutide 2.4 mg in Adults with Overweight or Obesity

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Results versus placebo: ALT decreased 25%, AST decreased 17%, fasting glucose decreased 6%

However, its impact on endosomal escape requires careful optimization, as PEG can hinder LNP fusion with endosomal membranes, a phenomenon often referred to as the PEG dilemma 174,175,176

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