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TB-500 and Cardiac Repair Research Research confirmed that the secreted peptide Thymosin beta-4 could inhibit myocardial cell death, stimulate vessel growth, and activate endogenous cardiac progenitors by returning the adult heart to an embryonically active programme with epicardial thickening and increases in myocardial and epicardial progenitors observed both with and without infarction, indicating that the reactivation process is independent of injury
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Its development has proceeded through phase 1, phase 2, and phase 3 trials, most prominently as the fixed-dose CagriSema combination with semaglutide, which has generated late-stage efficacy data but remains under regulatory evaluation rather than in approved clinical use
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