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Mitochondrial permeability transition pore in ASD Under physiological conditions, the IMM is impermeable to most molecules and ions

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Additionally, continued exposure of T cells at sites of inflammation elicits high levels of reactive oxygen species (ROS), which results decreased intracellular levels of GSH, dysregulation of redox balance, impaired signal transduction of the TCR/CD3 complex, and ultimately to synovial T cell hyporesponsiveness during RA [137]

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Stress management Chronic stress elevates cortisol, which suppresses tissue repair and promotes catabolism

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