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To prevent blood from flowing back into the legs, veins have valves that close if blood tries to flow backward

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Those who switched to placebo regained a significant portion, ending with only 9.9% loss from baseline

Matrix metalloproteinase-9 activation in hyperhomocysteinemic rats is triggered by the opening of the mitochondrial permeability transition pore and antagonism of the N-methyl-D-aspartate receptor-1 (NMDA-R1), resulting in myocyte dysfunction due to elevated calcium overload and oxidative stress [40]

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