Neuroscientists describe this as a dampening of dopamine signalling across reward pathways
Anti-inflammatory Properties : It effectively reduces inflammation, providing relief and hastening recovery from injuries and strain
However, when the landmark trials of semaglutide (STEP 1) and tirzepatide (SURMOUNT-1) measured body composition, they found that in some analyses, around 40% of weight loss came from LBM
A 2018 review paper found that the chance of developing symptoms of depression that were of clinical relevance is 3.3 times higher among patients with hypothyroidism compared with healthy controls. [6] In Hashimotos, there is a breakdown of the thyroid gland, which can rush thyroid hormones into the bloodstream, resulting in transient hyperthyroidism
Large-scale randomised controlled trials such as the STEP programme (semaglutide) and SCALE trials (liraglutide) reported pancreatitis as an uncommon adverse event (occurring in 0.1-1% of patients), with no clear signal for increased risk compared to placebo
Ohl K, Tenbrock K, Kipp M