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Manual corrections to the model were made using both ISOLDE and coot , with rounds of automated real space refinement performed using phenix v 1.21.1_5286 real space refine

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However, the children's pediatricians confirmed exclusion and inclusion criteria by completing the Pediatrician Form, which also provided details of general health and previous medical history and recommendation for participation in the trial

doi: 10.1007/s40618-020-01276-8 36 ImaiYKubaKRaoSHuanYGuoFGuanBet al