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Important Safety Information : Tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Chromatin immunoprecipitation and electrophoretic mobility shift analysis experiments suggest that p53 binds to the SLC7A11 locus at a specific p53 response element within the 5 untranslated region

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