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For example, metformin, a firstline agent in PCOS for insulin resistance, has been shown in patients with type 2 diabetes to blunt NET formation: in vitro, metformin prevented chromatin decondensation and DNA release and in vivo reduced circulating NET biomarkers (e.g., dsDNA, citrullinated histone H3) independent of glucoselowering effects [93]

428,429 HSPs are induced in response to various CNS pathologies, including neurodegenerative diseases, ischemia, and epilepsy, where they play a neuroprotective role by preventing protein aggregation and misfolding