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Another disease group that might benefit from treatment with incretin-based therapies is non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH)

Enzymes and stomach acids break down proteins quickly, meaning only a tiny fraction of an oral dose is successfully absorbed into systemic circulation

Andersson, L

When modified by NAPQI, Keap1 releases Nrf2, enabling its translocation into the nucleus, where it binds to antioxidant response elements in DNA and promotes transcription of genes encoding various antioxidant enzymes

One of its unique features is its prolonged half-life, meaning it stays active in the body for longer, leading to sustained growth hormone release

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