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The FDA approved it in 2012 for chronic weight management in adults with a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related comorbidity such as high blood pressure, type 2 diabetes, or high cholesterol

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Anal Chem 56:18901898 Kelly CP, Cramer CJ, Truhlar DG (2006) Aqueous solvation free energies of ions and ion-water clusters based on an accurate value for the absolute aqueous solvation free energy of the proton

A diminished availability of nitric oxide can lead to endothelial dysfunction (Jeong et al., 2022)

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NAC use is based on plotting APAP levels, on the Rumack-Matthew nomogram: Image from Wikipedia [Link is HERE] Intravenous NAC therapy includes: An initial dose of 150 mg/kg over 1 hour, A second dose of 50 mg/kg over 4 hours, And a final infusion of 100 mg/kg over 16 hours