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The agency applied the four-factor framework set out in 21 CFR 216.23(c), covering physical and chemical characterisation, safety, evidence of effectiveness, and historical use

Therefore, based on state-of-the-art evidence from PE literature (redox system, mitochondrial function/structure, and immunology), we will propose PE as a potential therapeutic strategy on vitiligo disease as summarized in Table 1

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Results: Inhibits cellular pigmentation

Ashwal S, Babikian T, Gardner-Nichols J, Freier MC, Tong KA, Holshouser BA (2006) Susceptibility-weighted imaging and proton magnetic resonance spectroscopy in assessment of outcome after pediatric traumatic brain injury

Freezing a liquid solution can damage the peptide structures