18, 23 Moreover, cells derived from solid tumors that undergo loss of attachment (LOA) to the extracellular matrix (known as anoikis) display inhibition of glucose uptake and catabolism, which results in the loss of ATP, NADPH (as a result of decreased flux through the pentose phosphate pathway) and increased production of reactive oxygen species (ROS)
Cardiovascular and metabolic benefits persist, and serious side effects remain rare
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If these intermediate metabolites are not quickly processed, they can cause massive cellular damage within the liver itself