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37% of US women who currently use GLP-1 medications do so because they were struggling to achieve results through diet and exercise alone, which is more than the 27% of male GLP-1 users who have the same motivation

However, the drink plenty of water caveat is crucial, as dehydration can exacerbate constipation from GLP-1 drugs, especially with the appetite-suppressing effects potentially leading to reduced fluid intake for those taking GLP-1 for weight management

Furthermore, these central effects may involve recruitment of pathways that are normally involved in stress and immune regulation, including adrenergic and opioid signaling and blocking either signaling pathway in rodent models again blunts the immunosuppressive effects of GLP-1RA, but this remains an area of active research as it whether this is also the case in humans

The Oncologist , 22 (3), 241e215

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