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therefore, prescribers usually restrict use to adults unless compelling justification exists

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

Biol Psychiatry

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A comparison of haloperidol with methadone in blocking heroin-withdrawal symptoms

1988 May;85(10):3653-6