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The SURPASS-J-combo trial embraced diabetic adults with HbA 1c 7% to 11% and BMI 23 kg/m 2 , stable weight and uncontrolled with therapy of metformin, thiazolidinedione, sulfonylureas, meglitinide, alpha-glucosidase inhibitor or SGLT2-i (81)

Am J Psychiatry 148 : 13011308

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In vitro studies suggest that may enhance endometrial receptivity by improving insulin signaling and inflammatory status in endometrial cells, thereby upregulating the expression of implantation-related molecules such as integrins (84, 86, 92)