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Under conditions of oxidative stress, the mitochondrial electron transport chain becomes less efficient, leading to increased production of superoxide radicals [86]
Piezo1 was verified to be a key mediator of ferroptosis in TMC
10.1016/j.arr.2021.101536 25 PaiV
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These alterations motivate the intestine to reduce mucus manufacture (Vaziri et al., 2012), destructive the intestinal epithelium (Hobby et al., 2019), disturbing the integrity of the intestinal barrier (Plata et al., 2019), changing intestinal permeability (Meijers et al., 2018), and permitting the microflora to be transported to the systemic circulation through the blood to act on the kidneys (Shi et al., 2014)
