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One possible mechanism involves epicardial adipose tissue, the fat surrounding the heart that has been linked to inflammation and electrical remodeling associated with AFib

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doi: 10.1038/s41467-021-25965-x 111 PaillardD.McKainN.ChaudharyL

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Rebound Weight Gain If semaglutide is discontinued, many users regain lost weight unless they maintain long-term healthy habits, including diet and exercise

Remarkably, this class of drugs has been showing promise in reducing cravings for other substances like alcohol, nicotine, cocaine, and even opioids