People in the second study used PAP machines
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Some groups, such as those with higher starting BMI or certain obesity-related health conditions, may see different results
Development of a formal clinical guideline, including specific dose-titration protocols, chronic kidney disease (CKD) considerations, and polypharmacy interactions, remains beyond the scope of this review and would require a dedicated systematic investigation
This approach can help sensitive individuals titrate more gradually, reducing the shock of jumping from one full dose level to the next
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