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The FDA has specifically warned that these salt forms have not been shown to be safe and effective, and their pharmacokinetic profile may differ from base semaglutide

Our narrative review discussed the CV benefits of GLP-1 RAs in terms of controlling CV risk factors and improving CV outcomes in diabetic and nondiabetic patients regardless of their CV history, and the CV perspectives related to their use in clinical practice

The intricate structural and biochemical interactions between skeletal muscle and the vascular endothelium facilitate optimal nutrient and oxygen transport, the clearance of metabolic byproducts, and the release of myokines and vasculokines that mutually regulate their respective functions (3, 4)

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Future Research Directions Novel Therapeutic Targets Emerging therapies targeting endothelial dysfunction, blood-brain barrier repair, inflammation, oxidative stress, and white matter regeneration are under investigation