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New pain management medications should exhibit higher response rates than existing options and aim to target specific pain pathways while improving understanding of dosing regimens and treatment cycles

GLP-1 receptor agonists work by reducing systemic inflammation and oxidative stress, which are two primary drivers of renal scarring

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however, the evidence comes from studies with heterogeneity and changing clinical practices

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Norman Swan : Remember, these are originally designed for people with type two diabetes, also in people with obesity, and particularly obesity and chronic diseases like heart disease and kidney damage, and they're very effective for that