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however, beyond adherence to the stipulated criteria for counseling on diet and physical activity, behavioral intervention was delivered by each study site with no further direction, allowing a degree of local tailoring and aiding real-world applicability

The honest limitation is that human clinical trials have not yet caught up to the preclinical evidence

Not evaluated or approved by the FDA

It is postulated that neurotransmitters or neurochemicals released by nerve endings, specifically substance P, can be toxic to melanocytes, causing their destruction in specific areas.92,93 The segmental distribution of vitiligo patches corresponds to the innervation of certain nerves, supporting this hypothesis.92,93 A study analyzing the presence of VZV in segmental vitiligo skin suggests a possible relationship between the 2

While GHK-Cu does support collagen pathways, which provides a mild firming effect to the skin's surface texture, it does not provide the structural tightening required to pull back loosely hanging folds of skin

Research indicates this may improve skin health