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and (ii) melatonin avoids mPTP opening and mitophagy-mediated cell death by suppressing mitochondrial fission following ischemia reperfusion injury that in turn restored bound VDAC1-HK2 (ref

This designation provides clarity on use context and helps researchers to comply with institutional and regulatory standards

doi:10.1016/j.chom.2014.03.012 178

A longer-term study, SURPASS-CVOT, is ongoing to evaluate the effect of tirzepatide on major cardiovascular events in overweight and obese adults, with an expected completion date of October 2024 [88]