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Iliceto S, Scrutinio D, Bruzzi P, D'Ambrosio G, Boni L, Di Biase M, Biasco G, Hugenholtz PG, Rizzon P

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Stress management Chronic psychological stress activates the hypothalamic-pituitary-adrenal (HPA) axis, producing cortisol that initially suppresses inflammation but eventually leads to cortisol resistance and a paradoxical increase in inflammatory signaling

Results showed that combination treatment with lower dose of metformin (0.1 mmol/L) and liraglutide (3 nmol/L) eliminated the inhibitory effects of PA (0.5 mmol/L) on the protein levels of GLP-1R (marginally) and p-PKA (completely)

E., Ogliaro F., Bearpark M., Heyd J

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