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International Journal of Pharmaceutics, 395 (1-2), 78-83

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But, insufficiency isnt as bad as frank deficiency, which can manifest in cases like cerebral atrophy, meaning brain shrinkage, in a Vitamin B12-deficient Infant of a Vegetarian Mother. Thankfully, even severe brain atrophy can be substantially reversed with B12 supplementation, but better not to become deficient in the first place