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Ein wichtiger Aspekt, um Falten vorzubeugen

doi: 10.1016/s0091-3057(02)00757-8

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Clock and Bmal1 encode for proteins containing bHlh-PAS domains, which form the positive arm of the feedback circuit by heterodimerizing to initiate transcription through binding to E-boxes (5-CACGTG-3) and (5-CACGTT-3) in the promoter of target genes