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In chronic wounds, the pathological microenvironment typically presents with acidic pH, elevated enzymes, ROS overproduction, and bacterial biofilms that hinder healing

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When you have an allergic reaction, it will activate your mast cells triggering an allergic response that will lead to the release of histamine and other chemicals

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Nature Communications , 8 , 15773

Biochimie 93, 1641-6 (2011)