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Proglucagon is a large precursor hormone molecule produced in the pancreas (alpha cells) and the intestines

Studies in fly models of PD treated with NAM, NAD + , or through PARP mutations demonstrated increased NAD + levels, which also rescued mitochondrial function 283,284,285

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We also demonstrated that this slower rate of activation is directly linked to PfK13 levels at the parasite periphery, by analysis of a PfK13 knock-sideways parasite line 8

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