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PMID: 29311918

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A major mechanism for the impact of oxidative stress on vascular tone is the decrease of nitric oxide (NO) bioavailability and/or signaling, leading to endothelial dysfunction, and ROS may also promote vascular cell proliferation and migration, inflammation and apoptosis, as well as extracellular matrix alterations

Abstract An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific