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GLP-1 medications can zap your energy in the first few weeks (or longer)

Lab work confirmed high inflammatory markers and antibodies

A systematic review of 35 studies found consistent age-related GSH decline in blood and specific brain regions, including the precuneus, hippocampus, cingulate, and frontal cortex

Less fluid in the gut means: Less lubrication Firmer stools Slower transit Dehydration also concentrates electrolytes like calcium, which can have constipating effects

Results showed that GLP-1R was detectable in vasculature, but mainly in smooth muscle