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In animal models (and in vitro work), it has been shown to release GH without substantially raising other hormones like ACTH or cortisol, which means less off-target hormonal disturbance

Ravussin, Y

In this systematic review, Bhandari et al

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In a strictly pharmacological sense, yes, GLP-1 begins working immediately

Quick Answer: GLP-1 works in the brain by binding to GLP-1 receptors distributed across multiple regions, triggering signalling cascades that suppress appetite, influence reward processing, and may protect neurons from damage