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3, 5, 7 and 8).The compounds were first tested as IMPDH2 inhibitors using inosine 5'-monophosphate (IMP) as a substrate (Supplementary Fig

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Regulatory status, labeling, and documentation differ

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In einer hnlichen kardiovaskulren Sicherheitsstudie an Cynomolgus-Affen mit intranasaler Verabreichung der nasalen Formulierung 1 wurde eine etwa eine Stunde dauernde Erektion an einem von vier Affen beobachtet.The Nasal Formulation 1 of Example 6 was performed by Cynomolgus monkeys administered a nasal spray at a dose of about 50 g / kg body weight