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Biochem Biophys Res Commun 177:10951100

Antioxidant and Anti-Fibrotic Effects: GHK-Cu provides copper-dependent activation of superoxide dismutase (SOD) and other antioxidant enzymes that neutralize reactive oxygen species

ROS, such as superoxide and hydrogen peroxide, amplify inflammatory responses and oxidative stress, thereby causing secondary tissue damage (119)

Upregulation of sense gene via NAT degradation While the previously mentioned mechanisms function to upregulate the sense gene by directly acting upon the sense gene mRNA transcript, one limitation lies in the fact that uORFs only exist in approximately 50% of mammalian mRNA and within this 50%, not all are inhibitory [106, 107]