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Historically only two of these criteria could be accomplished with a high degree of execution, with the third being sacrificed due to physical constraints of the delivery system architecture
Its proposed mechanisms involve multiple cytoprotective pathways including upregulation of VEGF and growth factors promoting angiogenesis, modulation of the nitric oxide system, activation of the FAK-paxillin pathway for cell migration and tissue repair, interaction with the gut-brain axis affecting dopaminergic and serotonergic systems, and gastroprotective effects against NSAID and alcohol-induced mucosal damage
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Sebecic et al., 1999
