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Research has demonstrated that GPER activation promotes insulin release via the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway and enhances pancreatic -cell function and survival [73]

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In the natural aging + FOXO4-DRI group, mice received intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days during the same period, followed by tissue collection