glp 1 gip mechanism Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) beyond Pleiotropic Physiological Effects Are Involved in Pathophysiology of Atherosclerosis and Coronary Artery Disease—State of the Art GLP-1 & GIP Agonists |

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Conclusion SGLT-2 inhibitors and GLP-1 receptor agonists reduce the risk of major cardiovascular events, heart failure, and stroke in type 2 diabetes patients, regardless of metformin use

It just creates a different one

the present invention provides copper peptide reservoir in gel form wherein gelling agent selected makes sustained release of copper peptide over considerable long time such that the patch shall not be changed over 12 hrs, preferably over 24 hrs and most preferably over 48 hrs

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"Understanding Diabetes -- Diagnosis and Treatment"