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Similarly, in vitro exposure of macrophages to 10 M of ACh prior to endotoxin challenge reduces TNF- production by increasing adenylyl cyclase 6 activity, leading to cAMP formation, CREB phosphorylation, and the expression of c-Fos, a known inhibitor of TNF transcription (85)

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Chem News 33:190 Fichman Y, Mittler R (2021) Integration of electric, calcium, reactive oxygen species and hydraulic signals during rapid systemic signaling in plants