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But this alone does not explain the specificity of the gene expression changes

In the airways it slows mucociliary clearance, injures the epithelial barrier, and depletes surfactant proteins, facilitating bacillary entry into the alveoli (Tilley et al., 2015

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Some have suggested that the overgrowth of Bacteroides may use excess tryptophan for microbial metabolism, thus reducing the supply of tryptophan for host serotonin synthesis, or conversely, enhance the accumulation of kynurenine catabolites that mediate fatigue (98)

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