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Further testing revealed that NETs were responsible for the binding of cholesterol and calcium crystals in the biliary fluid, resulting in the formation of gallstones

In lab and animal studies, researchers have documented several of its mechanisms: 1

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Iran J Basic Med Sci 27:297303

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Biodistribution studies showed that the presence of iron bound to transferrin in NZB/W mouse kidneys correlated with increased urinary protein, while non-transferrin-bound iron or ferritin had no effect on urinary protein levels