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2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Supplementary Table S1

Cycle length is typically 4 to 8 weeks, with a clinical review at the midpoint to assess response

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Weight loss typically becomes noticeable within the first 4 to 8 weeks, though individual results vary based on starting weight, metabolism, and lifestyle adherence