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Mechanistically, oxidative stress compromises mitochondrial integrity primarily through the activation of the ASK1JNKBcl-2/Bax apoptotic axis

Raafat Girgis, psychiatrist and clinical director at Moment of Clarity

Side-effect profiles vary by medication and individual tolerance

All 22 participants had previously been treated with a GLP-1 therapy for durations ranging from approximately 5 months to 5 years, with a mean total body weight loss of 24% while on therapy and a mean body weight of 80 kg 3 kg (SEM) at the time of intervention

When cytokine production increaseswithout proper regulationit can result in excess inflammation and higher risk of illness or autoimmune conditions

Therefore, future studies may seek to explore the beneficial effects of IL10 on TSPCs while mitigating its negative consequences