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Published research describes the following mechanisms for MC1R agonists like afamelanotide: NF-kappaB suppression reduced transcription of pro-inflammatory genes Cytokine modulation decreased TNF-alpha, IL-1beta, and IL-6 production Nitric oxide regulation normalization of NO pathway signaling Adhesion molecule downregulation reduced inflammatory cell migration IL-10 upregulation increased anti-inflammatory cytokine output These effects have been demonstrated in vitro and in animal models of acute, chronic, and systemic inflammation (Catania et al., 2004)

GLP-1 Glucagon-like peptide-1 (GLP-1) is an incretin hormone, a small protein messenger (gut peptides) that helps to regulate your appetite and tell you when you're full

Landek-Salgado MA, Faust TE, Sawa A

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