Finally, our study focused on the role of the PPAR/--catenin-TCF-4 pathway, but other potential pathways and interactions may also play a role and warrant further investigation
21 The MAESTRO-NASH trial 2224 reported that steatohepatitis resolved without worsening of fibrosis in 25.9% of patients receiving resmetirom 80 mg and in 29.9% of those receiving 100 mg, compared with 9.7% in the placebo group, and fibrosis improved without worsening of steatohepatitis in 24.2% and 25.9%, respectively, compared with 14.2% with placebo
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Acknowledgements The authors would like to thank Emire Bor, EMPIAR Center of Statistical Research and Consulting, for assistance with statistical analysis
The active form of thyroid hormone, T3, binds to thyroid receptors in the cell nucleus to turn on or off genes for transcription
However, most people rely on oral supplements