It is important to emphasise that, as an unlicensed investigational medicine in the UK, any adjustments to dose timing or frequency must follow the clinical trial protocol and be directed by your prescribing clinician or trial team
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GLP-1 medications carry important warnings and contraindications, including a boxed warning for thyroid C-cell tumors in rodents (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2)
The most frequently reported issues include nausea, constipation, headache, dizziness, insomnia, and dry mouth
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In the obesity trials, participants on the 12 mg dose reached up to roughly 2829% mean body-weight reduction at 68 to 80 weeks, with a large share crossing the 25% and 30% thresholds, the strongest weight result reported for a GLP-1-class compound in a phase 3 trial [5]
