Background GLP-1R agonists protect the blood-brain barrier (BBB): These drugs help maintain the integrity of the BBB by preventing tight junction degradation, which can reduce the risk of neuroinflammation and cognitive decline
Other manufacturers began synthesizing GLP-1 analogs with altered DPP-4 binding sites that bypassed degradation and remained in the body for weeks at a time [26]
Do not use testimonials to predict how much weight you will lose or whether a specific formulation is clinically appropriate
If youve started a GLP-1 medication and your energy feels lower than expected, youre not imagining it
The FDA approved this drug for use in weight management in Research from 2023 has found that people taking Wegovy lost more weight than those taking a placebo, with a mean difference in total weight loss of Zepbound Zepbound received FDA approval for use in weight management in Saxenda Saxenda received While Saxenda is effective for weight loss, people may notice slower or less obvious results
In contrast, Noom states that their dosing starts at 25% or less of the standard 0.25 mg dose and escalates at a personalized rate. While microdosing GLP-1 medications may provide a more personalized experience, there are still questions regarding the safety of this practice as there are currently no published studies on the process, and the microdoses may come from a compounding pharmacy
