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GSH depletion-dependent cell death was prevented by selective ferroptosis inhibitors (8 M Fer-1 and 600 nM Lip-1), iron chelator DFO (80 M), as well as autophagic inhibitors Baf-A1 (75 nM) and 3-MA (10 mM)

8d), 8-OHdG (Fig

In contrast to earlier GLP-1 receptor agonists, which primarily target appetite suppression and glycemic improvement, GLP-3 leverages GCG receptor activation to stimulate lipolysis and elevate basal metabolic rate, thereby contributing to a more pronounced and sustained reduction in adiposity as observed in research models

Patients often notice they can comfortably adhere to smaller portions, avoid excessive snacking, and make healthier choices without feeling deprived

Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes

Br J Surg 77(4):368372