Despite this activity, GSPT1 degradation represents a promising potential therapeutic strategy, since GSPT1 dysregulation or increased expression is associated with multiple cancers
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In a diabetes MRI substudy, liver fat fell up to 47% at 15 mg versus about 11% on insulin. In biopsy-confirmed fatty-liver disease with fibrosis, a large share of participants on 15 mg had disease resolution versus a small share on placebo. These are not microdose data
